Well, as odd as it seems, the common denominator appears to be GT Chris Jones. (with or without Blitz) After reshuffling, adding removing, tweaking AP's, all along my roster, they only time I don't get a desynch is when I completely remove Jones. If I leave him as a backup and even remove all his non-baked on AP's, I get desynched on the first run play. Started the day in Ranked with a desynch to set the baseline, removed Jones and went on 6 game win streak. Put him in as DT1, desynch. Replaced him and stuck at RDT2, desynch. Tried him in a few places for a few games and always ended in a desynch. I've left him on the bench and finished 3 games. I'm done for the day.

There's no way something like this should happen this suddenly this late in the game with no explanation.