I just had a guy matriculate down the field with nonstop RPO's my defenders refused to cover no matter what I told them.
When I tried to manually defend, he audibled and went with a different cheese play.
Why do I do this to myself. On the field, I could cover this with my barely-sub-6.00 40-time SPD. As a coach, I could tell a superior athlete to stop this. In Madden, my defenders go on strike.
I also wondered a bit whether DDA was a factor, as the dude had a significantly weaker team overall. But he was one-dimensional cheese out of the gate, and I just couldn't stop it.